versão ISSN 1029-3019
Advances in the cellular and molecular biology have allowed a better understanding of the meaning of cancer. Many researchers agree about an orderly and sequential occurrence of tumor progression in each of the most frequent human tumors, the presence of "gatekeeper and caretaker genes" that regulate the sense of this development, the adaptative nature of the mutations underlying carcinogenesis, among others. It seems that induced genetic variability and genetic polymorphism influence decisively the susceptibility for the onset of neoplasia.
Palavras-chave : cancer; tumor progression; carcinogenesis; induced genetic variability; genetic polymorphism.