Abstract

ESTRADA PEREIRA, Gladys Aída; MARQUEZ FILIU, Maricel  and  GONZALEZ HEREDIA, Eugenia. Clinical and histopathological diagnosis of oral leukoplakia. MEDISAN [online]. 2012, vol.16, n.3, pp.319-325. ISSN 1029-3019.

A descriptive and cross-sectional study was carried out in 116 patients with oral leukoplakia, assisted in the Stomatology Department of the Specialties Polyclinic belonging to "Saturnino Lora Torres" Teaching Clinical Surgical Provincial Hospital in Santiago de Cuba, from June, 2007 to the same month of 2010, in order to evaluate the results of the clinical and histopathological diagnosis of this disorder and their relation to the smoking habit and subjective symptoms. The samples for biopsies were deposited in a glass flask with 10 % formol, they were fixed in 5 % formaline, they were processed through the classic technique of inclusion in paraffin and then they were colored with hematoxiline-eosine, through which the presence of cellular changes was confirmed. Male sex, the absence of these symptoms, the epithelial dysplasia and the hyperparakeratosis prevailed in the case material, as the most common epithelial changes, as well as the severe dysplasia in heavier smokers. On the bases of the detected transformations, investigations allowing to specify the biological and histological implications of this disease should be carried out.

Keywords : oral leukoplakia; histopathological diagnosis; biopsy; hyperkeratosis; epithelial displasia; subepithelial inflammatory infiltrate.

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