Abstract

CESPEDES QUEVEDO, María Cristina; LEON BARRIOS, Yeris Leydis; VINENT CESPEDES, Ana Margarita  and  EDWARDS SERINGE, Sarah. Neutropenia induced by chemotherapy in patients with breast cancer. MEDISAN [online]. 2015, vol.19, n.2, pp.199-207. ISSN 1029-3019.

A descriptive, cross-sectional and prospective study of 201 patients with breast cancer assisted in the Chemotherapy Service of "Conrado Benítez García" Teaching Provincial Oncological Hospital in Santiago de Cuba was carried out during a year (from June, 2013 to the same month of 2014), in order to characterize them and to determine neutropenia as adverse reaction to the treatment. The information was analyzed statistically by means of the percentage calculation and the test Chi squared test, with which it was obtained that 82 patients suffered neutropenia (40.7%) in whom the age group 41- 60 years prevailed (50.0%), the clinical stage II of the malignant tumor (65.8%) and just one neutropenia episode (90.2%). As for the patients diagnosed with neutropenia, 91 episodes were registered, with higher frequency of the moderated degrees (52.7%) and mild (39.5%), and a favorable reaction to the stimulating factor of human granulocytes colonies 81.8% of them. Lastly, the neutropenia existence as adverse effect to the cytostatic drugs in almost 50% of the patients was demonstrated, as well as the beneficial result of the stimulating factor in them; however, there was no association between the different combinations of cytostatic drugs and the episodes and neutropenia degrees

Keywords : neutropenias; breast cancer; chemotherapy; cytostatic drug; stimulating factor of human granulocytes colonies.

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