Abstract

BASAIN VALDES, José María; VALDES ALONSO, María del Carmen; PEREZ MARTINEZ, Margarita  and  MARTINEZ IZQUIERDO, Alicia. Activation of the Toll-like receptors in the adipose cell: their influence in the beginning and permanence of obesity. MEDISAN [online]. 2016, vol.20, n.7, pp.970-978. ISSN 1029-3019.

Infantile obesity constitutes an important health problem at the present time that is experiencing an increment in the entire world. In obese people the excess of white adipic tissue generates a low degree chronic inflammatory response, when increasing the secretion of inflammatory molecules and diminishing the anti-inflammatory ones -- adiponectin and cytosine --. At the moment it is recognized that the adipic tissue possesses implications in the innate immunity because in the adipose cell, Toll-like receptors are expressed and drive to a cascade of intracelular signaling when being activated, and the beginning of an inflammatory response is promoted this way. Due to the importance of the topic, in this work this cellular process and its influence in the beginning and the perpetuation of the proinflamatory state in the obesity is described

Keywords : obesity; adipose cell; proinflamatory state; innate immunity; Toll-like receptors.

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