Resumen

CABRERA LAVERNIA, Jorge Omar; RICARDO SERRANO, Yoel Mario  y  NOGUERA BERCHI, Cristina Beatriz. Predictors of Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis. CCM [online]. 2014, vol.18, n.1, pp.33-44. ISSN 1560-4381.

Introduction: nonalcoholic fatty liver disease is the most common cause of chronic liver disease, half of these patients develop nonalcoholic steatohepatitis. Objective: to determine by using anthropometrics, clinics and biochemical factors a discriminant function and identify the most useful ones to predict liver fibrosis in  patient with nonalcoholic steatohepatitis. Methods: a case control study in 62 patients who underwent liver biopsy at Gastroenterology Service, between July 2005 to November 2012 at Carlos Manuel de Céspedes Hospital in Bayamo was carried out. Results: 21 patients (33.8%) presented liver fibrosis, the mean values of waist circumference, body mass index, cholesterol, triglycerides, C reactive protein and blood glucose was significant higher (p<0.00) in patient who developed liver fibrosis, the proportion of diabetes and hypertension was higher too (p<0.000), nevertheless the transaminases values and the age do not discriminated between both groups and gender was not associated with fibrosis. Conclusions: the discriminant equation calculated with blood glucose, waist circumference, C reactive protein and triglycerides classified correctly more than two third part of the patient with fibrosis and the diagnostic performance was better than BARD index.

Palabras clave : steatohepatitis; liver fibrosis; liver biopsy.

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