Resumen

GALVIS, Fabián; RIVERO-LOPEZ, Esmeralda  y  CARDENAS, Denny. Polymorphisms in MTHFR and IL-10 Genes and Risk Factors in Patients with Gastric Cancer in the Municipality of San José de Cúcuta, Colombia. ccm [online]. 2017, vol.21, n.2, pp.487-500. ISSN 1560-4381.

Introduction: gastric cancer is one of more concern neoplasms around the world due to its incidence and associated mortality. Helicobacter pylori infection, host genetic susceptibility and environmental factors are considered the causes of gastric carcinoma occurrence. Objective: to evaluate the C677T, A592C and T819C polymorphisms and risk factors in patients with gastric cancer in the municipality of San José de Cúcuta. Methods: application of surveys for determining risk factors, detection of serologic response to H. pylori infection, genotyping of polymorphisms using PCR-RFLP and statistical analysis. Results: the analysis of risk factors in the cases showed consumption of tobacco, alcohol, and salt in 68.8% and H. pylori infection in 75% of cases; 68.8% had a family history of cancer and 75% had preexisting gastric disease. The control population had lower consumption of alcohol and tobacco comparing to the cases group, high consumption of vegetables (64%) and similar value of H. pylori infection (80%). Analysis of the C677T polymorphism revealed predominance of the wild-type allele in both cases and controls with no evidence of association with the developing of gastric cancer; the polymorphisms A592C and T819C presented higher frequency of the mutated allele in both groups, with no significant differences between cases and controls. Conclusions: although no significant differences were observed in the genetic variants, different patterns were detected between cases and controls regarding the evaluation of environmental factors, which would probably explain the absence of the disease in healthy individuals.

Palabras clave : gastric cancer; interleukin-10; MTHFR; single nucleotide polymorphism; PCR; RFLP.

        · resumen en Español     · texto en Español     · Español ( pdf )