Resumen

FERIA DIAZ, Gisela Eduarda et al. Role of cytokines in the physiopathology of rheumatoid arthritis. ccm [online]. 2020, vol.24, n.1, pp. 341-360.  Epub 01-Mar-2020. ISSN 1560-4381.

Rheumatoid arthritis is a chronic systemic disease of multifactorial etiology that affects the joints. Its physiopathology is not well known, but it indicates that there is a relevant role of cytokines as molecules which interrelate immune and neuroendocrine system disorders with environmental factors. This review describes the role of proinflammatory cytokines in the physiopathogenesis of rheumatoid arthritis and the practical application of this knowledge in the design of new medications for the treatment of this disease. For this work MedLine, MedicalKey and SciELO databases were reviewed with the descriptors cytokines and rheumatoid arthritis in Spanish and English. They were filtered mainly for quotable articles published in the last 5 years. Cuban biomedical journals were also reviewed.

Palabras clave : rheumatoid arthritis; cytokines; physiopathology; autoimmunity; inflammation.

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