Abstract

ALVAREZ ALVAREZ, Aimée et al. Glycemia, insulinemia and insulin secretion in prepubescent rats receiving high doses of androgens and strogens. Rev Cubana Endocrinol [online]. 2001, vol.12, n.1, pp. 0-0. ISSN 1561-2953.

The effect of an overdose of testosterone heptanoate and estradiol in male prepubescent rats on the behavior of glycemia and insulinemia was studied in vivo during a glucose tolerance test. The capacity of insulin secretion stimulated by glucose from the islets of Langerhans of these rats that were administered a high dose of androgens and estrogens was explored in vitro. It was found that the high level of circulating androgens was accompanied by a deterioration of sensitivity to insulin with hyperinsulinemia that does not correspond to an increase of the insulin secreting capacity of the islets of Langerhans. However, it was demonstrated that the high level of circulating estrogens did not produce changes either in the glycemia and insulinemia profiles or in the insulin secreting capacity of the islets of Langerhans in this group of rats that received an elevated dose of estrogens.

Keywords : HEPTANOATES; ESTRADIOL; RATS; INBRED STRAINS; HYPERINSULINISM; ISLETS OF LANGERHANS; GLUCOSE TOLERANCE TEST.