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Revista Cubana de Endocrinología

versión On-line ISSN 1561-2953

Resumen

OCHOA TORRES, Francisco  y  RUIZ HERNANDEZ, Luis. Value of the determination of plasmatic antithyroid antibodies for the diagnosis of chronic autoimmune thyroiditis . Rev Cubana Endocrinol [online]. 2001, vol.12, n.2. ISSN 1561-2953.

The effectiveness of the humoral antibody detection methods used in the diagnosis of chronic autoimmune thyroiditis (CAT) in the National Institute of Endocrinology was assessed. A group of 100 patients with goitier and presenting with clinical suspicion of CAT was studied. A fine needle biopsy was performed on each of the patients, which was taken as the golden rule of the diagnosis and also the determination of plasmatic antithyroglobulin antibodies by the TCR method and the determination of antimicrosomal antibodies were made for statistically validating both methods, taking sensitivity, specificity, predictive value for positive cases, predictive value for negative cases and general index of diagnostic efficacy into consideration. Seventy patients were found positive and 30 negative for CAT by the FNB. The sensitivity of both methods of humoral antibodies was poor: 45.7 % for AMS and 30 % for TRC. Even the joint application of both methods to the same patient did not exceed 60 %. Specificity was a much better indicator in both methods (73.3 % for AMS, 90 % for TRC and 70 % for both applied together). The predictive value for positive cases was good (80 % for AMS; 87.5 % for TRC and 82.3 % for both) and the predictive value for negative cases was 36.3, 35.5 and 42.9 % respectively. The general efficacy was only 54 % for TRC, 48 % for AMS and 63 % for both methods together. It was concluded that these procedures are useful to confirm the diagnosis when cases are positive, but they are rather useless to assure the non-existence of this affection when cases are negative

Palabras clave : THYROIDITIS, AUTOIMMUNE [diagnosis]; THYROIDITIS, AUTOIMMUNE [pathology]; BIOPSY, NEEDLE; AUTOANTIBODIES; GOITIER [pathology].

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