Revista Cubana de Endocrinología
versión On-line ISSN 1561-2953
HUGUES HERNANDORENA, Beatriz; CESAR RODRIGUEZ GONZALEZ, Julio y RODRIGUEZ GARCIA, Julio César. Laboratory animals in endocrinology: Biomodels of type I diabetes mellitus. Rev Cubana Endocrinol [online]. 2001, vol.12, n.3, pp. 168-177. ISSN 1561-2953.
In biomedical research, it is necessary the use of laboratory animals as natural or induced models of different diseases or morbid processes that make easy the study and understanding of the pathogeny, physiology and possibilities of treatment of them. In endocrinology, they are utilized to study the aspects of the diseases of autoimmune origin or of those not related to this system, such as diabetes mellitus, thyroid dysfunctions, reproduction and metabolism disorders, among others. Besides, they are also an important tool to investigate the hormonal interrelations occurring in normal or sick individuals. A wide bibliographic review on this topic was made to give a detailed information about the animal models of type I diabetes mellitus used in biomedical research, including those obtained in a spontaneous or induced way, as well as the influence of the environmental factors on them. It was concluded that it is very important for the achievement of the basic research in vivo to maintain a strict control of the environmental conditions under which we develop our investigations and to improve our knowledge on this topic.
Palabras llave : ANIMALS, LABORATORY; DIABETES MELLITUS, INSULIN-DEPENDENT; RESEARCH.