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Revista Cubana de Endocrinología

versión On-line ISSN 1561-2953


Transeptosphenoidal surgery in prolactin-secreting hypophyseal adenomas. Rev Cubana Endocrinol [online]. 2005, vol.16, n.2. ISSN 1561-2953.

The current treatment of prolactinomas is basically medical due to the good results attained with the new dopaminergic agonists. However, the selective adenomectomy is among the treatment modalities for those prolactinomas that do not respond to it. The objective of the present paper was to evaluate the results of the microsurgical transeptosphenoidal treatment of the prolactin-secreting adenomas at the service of Neurosurgery of “Hermanos Ameijeiras” Hospital. To this end, we conducted a retrospective descriptive study of 63 patients carriers of this type of adenomas that underwent sublabial transeptosphenoidal microsurgery and were treated in our service from 1996 to 2003. Age, sex, the clinical picture, the size of the lesions, the hormonal levels, as well as the complications and the postoperative evolution were analyzed. As a result, it was found a predominance of females: 86 % (54 patients). 31 patients with macroadenomas and 32 with microadenomas were operated on. The most frequent symptoms improved, mainly headaches, in 82 % (36 cases). The most common complication in the postoperative was temporary diabetes insipidus (11 patients). It was possible to reduce the initial figures of prolactin to non-tumoral values in 90.6 % of the microadenomas (29 cases) and in 67.7 % of the macroadenomas (21 cases). It is concluded that transeptosphenoidal adenomectomy is a safe and efficient procedure as an option treatment for patients with prolactin-secreting adenomas with surgical indication.  

Palabras clave : Transeptosphenoidal surgery; prolactinomas; microsurgical treatment.

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