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Revista Cubana de Endocrinología

versión On-line ISSN 1561-2953

Resumen

NAVARRO DESPAIGNE, Daysi  y  MORALES CABRERA, Néstor. Effect of replacement hormone therapy on mammography: our experience in this field. Rev Cubana Endocrinol [online]. 2005, vol.16, n.3. ISSN 1561-2953.

A retrospective study was conducted, with the objective of describing the effect of hormone replacement therapy (HRT) on mammography performed on middle-aged females, who had been seen at climacterics and osteoporosis clinics from January 1998 to December 2003. Mammography had been performed on each woman at the beginning and during the use of the HRT, being the results as follows: 1) mammography showing no changes; 2) mammography with slight changes irregular density and microcalcification and 3) mammography with major changes nodules, cysts or any other change . As a treatment, they received estrogen (E), continuos combined estrogen and progestagen (EP) and nonestrogen therapy (phytoestrogen, tibolone). The sample was composed of 112 women aged 34 to 59 years. The initial Mx showed no changes in 85,5 %, slight changes in 9,1 and major changes in 5,4 of females. After the application of HRT (average time between both mammographic studies of 2,5 years), 66 % of females continued showing no changes, 29 and 5 % had slight (p<0,05) and major changes respectively. Continuos combined therapy exhibited the highest frequency of changes. Those females without estrogen therapy showed no changes in mammography breast pattern. On balance, the results achieved in our context were comparable to those reported in other parts of the world about the effect of hormone replacement therapy on mammography breast density.

Palabras clave : Replacement hormone therapy; mammography; middle age; menopause.

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