Resumen

ESPINOSA REYES, Tania Mayvel  y  MARICHAL MADRAZO, Sigrid. Advances in insulin-therapy in type 1 diabetes mellitus: Success and failures. Rev Cubana Endocrinol [online]. 2007, vol.18, n.1. ISSN 1561-2953.

History of development of pharmacological treatment of diabetes had an essential chapter in descovery of insulin and its introduction as therapy of Type 1 diabetes. Knowledge of its complications, lead to the need of a more sophisticated therapy. Since then, insulin preparations and therapeutical strategies has been initially developing at the expense of insulin origin, and then with incorporation of substances modifying its absorption. As long as in 1990, emerged insulin analogues with an special change ability in its pharmacokinetics. Then, new ways of release were introduced, e.g. continuous infusion pumps, aerosols, and all this supported by new systems of glucose monitoring. In the pas decade, islet transplant and gen therapy with obtention of ß cells from pluripotential stem cells, increase expectation in this field. All these elements confirm the endless path in the search of efficaceous therapeutics in treatment of Type 1 diabetes mellitus. Aim of this paper is to expose main advances on the subject of insulin therapy and to think over sucess and failures in its introduction.

Palabras clave : Insulin analogues; continous infusion pumps; aerosols; monitoring systems.