Revista Cubana de Endocrinología
On-line version ISSN 1561-2953
ACOSTA CEDENO, Alina et al. Bone quality in middle-aged females with type 2 diabetes mellitus. Rev Cubana Endocrinol [online]. 2008, vol.19, n.1, pp. 0-0. ISSN 1561-2953.
BACKGROUND: osteoporosis and diabetes mellitus are health problems for the aging population in general and for females in particular. The metabolic decontrol and the microvascular lesions of DM affect the whole organism, including bones. OBJECTIVE: to determine the quality of bones in middle-aged females with type 2 diabetes mellitus. METHODS: a cross-sectional descriptive study was conducted to determine the bone quality in 30 females with type 2 DM, and in 20 without DM that were in the control group. Medical history was made to know age, body mass index, hip circumference and physical activity. In the diabetic, the time of evolution of diabetes mellitus, fasting glycaemia and 2-hour postprandial glycaemia, were also determined. Bone quality was defined by "LEXUS" densitometer, and it was expressed as bone mineral content and T-score in L2-L4 and radius. The World Health Organization's criteria were used to define osteoporosis. Descriptive statistics and lineal correlations were also used. RESULTS: 33 % of the patients with type 2 diabetes mellitus had osteoporosis in radius, and 3.3 % in L2-L4, which occurred in 75 and 30 % of the non-diabetic, respectively. The bone mineral content in L2-L4 of the diabetic was 0.561 g/cm2, whereas in radius it was 0.358 g/cm2. In the non-diabetic, it was 0.285 and 0.313 g/cm2, respectively (p<0,01 sig). The T-score of L2-L4 and radius in both groups was better in those patients with an adequate physical activity. In patients with type 2 DM, it was observed a positive significant association of the body mass index > 18.5 kg/cm2 cs and the hip circumference > 88 cm with the bone mineral content. There was a negative association between the T-score in Radius and fasting glycaemia ³ 7 mmol/L, and between the time of evolution > 5 years and the bone mineral content in L2-L4 (p<0.05). CONCLUSIONS: in our study, the bone quality in females with type 2 diabetes mellitus was better than in those with no diabetes mellitus.
Keywords : Diabetes mellitus; osteoporosis; climacteric; densitometry.