Resumo

GONZALEZ SUAREZ, Roberto M.; PERICH AMADOR, Pedro  e  ARRANZ CALZADO, Celeste. Metabolic disorders and its diversity during early stages of type 2 diabetes mellitus. Rev Cubana Endocrinol [online]. 2009, vol.20, n.1. ISSN 1561-2953.

BACKGROUNDS: the prediabetes has been defined as a risk situation related with the presence of future diabetes, preceding appearance of clinical ways of the disease, and it is provoked by disorders from insulin secretion and the sensitivity to insulin. OBJECTIVE: to establish a metabolic disorders profile from a group of subjects in the diabetes mellitus subclinical stage to identify subpopulations sensitive to specific interventions. METHODS: we used the information gathered on glucose tolerance stage, on insulin-sensitivity, and on insulin secretion in an initial study of 40 patients participating in a prospective research, which two years later were diagnosed with manifest diabetes. RESULTS: subjects with initial diabetes mellitus had a wide range of disorders related to a glucose tolerance (tolerance to normal glucose (22 %), tolerance to altered glucose (35 %), and tolerance to altered glucose + altered fast glycemia (43 %). The 95 % of the obese subjects and the 50% of the non-obese ones had a insulin resistance, whereas there was a decrease of insulin secretion in 50 % of subjects of both groups. There as not a association between deterioration level of tolerance to glucose and study metabolic disorders. CONCLUSIONS: subjects in early stages of diabetes are a heterogeneous population with different levels of energy metabolism deterioration, where interventions to prevent diabetes in these persons need a diagnosis and personalized treatment.

Palavras-chave : Non-insulin-dependent diabetes mellitus; prediabetes; intolerance to glucose; glucose-tolerance test; resistance to glucose; decrease insulin secretion.

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