Revista Cubana de Endocrinología
versão On-line ISSN 1561-2953
LICEA PUIG, Manuel Emiliano; SINGH LINARES, Omar e GARCIGA CARDOSO, Francisco. Microalbuminuria and its association with left ventricular dysfunction in normotensive subjects presenting with type 1 diabetes mellitus. Rev Cubana Endocrinol [online]. 2009, vol.20, n.1, pp. 0-0. ISSN 1561-2953.
BACKGROUNDS: left ventricular dysfunction is a frequent complication in persons presenting with type 1 diabetes mellitus. OBJECTIVE: to determine if albumin urinary excretion is associated with the presence of left ventricular dysfunction (LVD) in normotensive persons presenting with type diabetes mellitus of a long evolution. METHODS: we made a descriptive and cross-sectional study in 80 normotensive type 1 diabetic patients aged between 15 and 40 with a ³10 years of type 1 diabetes mellitus evolution seen in a consecutive way in our service. Other diseases were excluded or those conditions provoking per se left ventricular dysfunction and proteinuria. Study includes: age, sex, body mass index (BMI), smoking, arterial pressure, type 1 diabetes mellitus evolution, diabetic retinopathy, incipient diabetic nephropathy, 2-hours fast and postprandial glycemia, glucosilated-hemoglobin (HbA1), 24-hours albumin urinary excretion, creatinine, electrocardiogram, and two-dimensional M-mode echocardiogram with pulsed Doppler. RESULTS: we verified left ventricular dysfunction (LVD) in 26,3 % and structural alterations in 16,2 %. Incipient diabetic nephropathy frequency was higher (p<0,032) in LVD group (80,9 % versus 57,6 %). Albumin urinary excretion was higher too (p<0,020) in patients presenting with LVD. CONCLUSIONS: LVD is frequent in type 1 diabetes mellitus with a long evolution. Albumin urinary excretion (microalbuminuria) is associated with presence of LVD. LVD-associated factors include a greater evolution time, postprandial glycemia, and HbA1.
Palavras-chave : Incipient diabetic nephropathy; albumin urinary excretion; LVD; microalbuminuria; diabetic disease of cardiac muscle; type 1 diabetes mellitus.