Revista Cubana de Endocrinología
On-line version ISSN 1561-2953
GARCIA GARCIA, Yudit; MONTEAGUDO PENA, Gilda; PADRON DURAN, Rubén S. and GONZALEZ SUAREZ, Roberto. Evaluation of insulin-sensitivity in polycistic ovary syndrome. Rev Cubana Endocrinol [online]. 2009, vol.20, n.3, pp. 131-140. ISSN 1561-2953.
INTRODUCTION: women with polycistic ovary syndrome have a increasing risk of insulin resistance, dyslipidemia, obesity, hypertension and type 2 diabetes mellitus; thus, with higher likelihood to develop cardiovascular disease. OBJECTIVE: to determine the frequency and features of insulin sensitivity disorders in a group of women with polycistic ovary syndrome. METHODS: twenty three women with this diagnosis were studied according to the Androgen Excess Society (AES) criteria,underwent basal glycemia and insulinemia determinations and during frequently sampled intravenous glucose tolerance test). Several insulin sensitivity and insulin resistance mathematic indexes were calculated. RESULTS: sixty-five percent of women had insulin resistance (HOMA-IR ³ 3.22 rate). Analysis of area under the curve of insulin during the test revealed that women with insulin resistance had higher insulinemia rates in baseline state and post-stimulation;in both groups concentrations were similar to the initial ones at the end of test. Glycemia and insulinemia 0-10 areas and insulin area were higher in women with insulin resistance. All indexes including Io/Go, FIRI, ISI, Belfiore, BENNET and QUICKI had a good correlation with HOMA-IR. CONCLUSIONS: insulin resistance and hyperinsulinism frequency in women with policystic ovary syndrome was high and the fasting insulin resistance assessment may to predict the response during the glucose-intravenous stimulation.
Keywords : polycistic ovary syndrome; frequently sampled intravenous glucose tolerance test; insulin resistance; insulin sensitivity indexes.