Resumen

NAVARRO DESPAIGNE, Daysi Antonia. Bone quality in middle age women presenting with pharmacological subclinical hyperthyroidism. Rev Cubana Endocrinol [online]. 2010, vol.21, n.3, pp.297-306. ISSN 1561-2953.

INTRODUCTION: thyroid hormones at supraphysiological levels and the hypothyroidism are factors that may to induce a low bone mass. OBJETIVE: to determine the bone quality in climacteric women under treatment with suppressive doses with thyroid hormones. METHODS: the case-control study conducted between March, 2006 and December, 2008 includes 113 women aged 40-59 seen in external consultation of National Institutes of Endocrinology, Oncology and Radiobiology where 43 of them were under treatment with thyroid hormones (study group) and 70 not (control group). Using dual beam absorptiometry of lumbar spine and the forearm, it was possible to determine the bone mineral density in g/cm² and the T pointing to identify the presence of osteopenia or a low bone mass and osteoporosis. RESULTS: the bone mineral density of lumbar spine and forearm was of 0,9229 vs. 0,8856 (p<0,05) and of 0,536 vs. 0,6226 (p<0,05) for patients of study group. With treatment using thyroid hormones there was less mineral content in both anatomical sites, although the involvement if greater in the forearm (p<0,05). Fracture risk (osteopenia+osteoporosis) in lumbar spine was of 44,1 % and of 50 % and in the forearm was of 44,8 and 42,7 %, respectively for women from both groups. CONCLUSIONS: the use of thyroid hormones in suppressive doses decreased the bone mineral content in forearm with no increase of facture risk.

Palabras clave : Bone quality; bone mass; thyroid hormones; mean age; thyroid cancer.

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