Resumen

MARRERO RODRIGUEZ, María Teresa. Methylation and expression of genes in thyroid differentiated cancer. Rev Cubana Endocrinol [online]. 2010, vol.21, n.3, pp.340-350. ISSN 1561-2953.

In past years the study of epigenetic alterations in the cancer development becomes significance. The methylation of desoxyribonucleic acid is the more frequent and important epigenetic change until now studied and play a significant role in the transcription regulation of genes. Recently it was noted the existence of abnormal methylation patterns in many types of cancer, including the thyroid one, which leading to inactivation of tumor suppressors genes and to genome instability. The methylation of specific genes such as the co-transporter of iodine/sodium, the thyroglobulin and the receptor of thyroid stimulant hormone (TSH) in the thyroid differentiated cancer, is one of the failure cause in treatment of patients presenting this disease. In patients with thyroid cancer it has been initiated a treatment with demethylation agents in patients with abovementioned cancer with a genetic alteration due to methylation to correct these alterations, to restore the function and thus the possibility of a effective treatment.

Palabras clave : Epigenetic; methylation; demethylation agents; desoxyribonucleic acid (DNA); genes; thyroid differentiated cancer.

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