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Revista Cubana de Endocrinología
versión On-line ISSN 1561-2953
Resumen
ESCOBAR AEDO, Adrián Luis et al. Effect of Vimang® supplementation on oxidative stress markers in young patients with type 1 diabetes mellitus. Rev Cubana Endocrinol [online]. 2011, vol.22, n.2, pp.103-117. ISSN 1561-2953.
Introduction: the oxidative stress plays a fundamental role in the pathogenesis of diabetes mellitus complications. Vimang® (a natural antioxidant product) has been successfully used diseases characterized by an increase of oxidative stress. Objective: to assess the effect of Vimang® on the redox state in young people presenting with type 1 diabetes mellitus. Methods: a phase II clinical, randomized, controlled unicenter trial to assess the antioxidant effectiveness tablets Vimang® in young people with type 1 diabetes mellitus including 50 patients located into two groups (25 each) who received 300 mg tablets Vimang® every eight hours and placebo, respectively was carried out. The glycemia control was assessed by glycosylated hemoglobin, a complete lipidic profile and hemochemical determinations were carried out. The variables of damage due to oxidative stress were assessed: peroxidation potential, total hydroperoxides, advanced products of the protein oxidation, malonylaldehyde and the reduced glutathione endogenous antioxidant. Determinations were made before and at 3 months of intervention. Groups were compared each other, in the two times as well as in an internally regarding the basal state previous to supplementation with Vimang® or placebo. Results: the peroxidation potential increased at three months in both groups (p < 0,05), only decreased in the 25 % of the patients under supplementation. There was an increase of malonylaldehyde (p < 0,05), of total hydroperoxides (p < 0,01) and a also a decrease of reduced glutathione (p = 0,01) at three months in patients under treatment. It was neither related to supplementation nor to metabolic control, which improved in both groups. Conclusions: Vimang® was not an effective antioxidant in the dose used in type 1 diabetes mellitus patients.
Palabras clave : Type 1 diabetes mellitus; Vimang®; oxidative stress; antioxidants.