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Revista Cubana de Endocrinología

versión On-line ISSN 1561-2953

Resumen

CONESA GONZALEZ, Ana Ibis  y  GONZALEZ CALERO, Teresa Margarita. Most recent aspects about type MODY diabetes mellitus. Rev Cubana Endocrinol [online]. 2012, vol.23, n.2, pp.186-194. ISSN 1561-2953.

Background: a better physiopathological understanding of diabetes mellitus allows identifying its different types such as a monogenic variant called MODY (maturity-onset diabetes of the young). Objectives: to describe the physiopathological, clinical, diagnostic and therapeutic aspects of the different subtypes in MODY diabetes. Development: the patients with MODY diabetes behave similarly to those suffering diabetes mellitus in adults. It is characterized by inherited dominant autosomal genetic alteration which is primary to a defect in insulin secretion. Up to the present, 9 subtypes are accepted. The subtypes 1,3,4,5 and 6 affect gens coding for nuclear transcriptional factors whereas subtype 2 affects the gen coding for glycokinase enzyme. From the clinical viewpoint, they are characterized by conditions ranging from permanent, slight or moderate hyperglycemias, with good clinical prognosis and low complications, to sustained hyperglycemias accompanied by early chronic and serious complications. Conclusions: the people suffering MODY diabetes are not as uncommon as one might think. The correct and early detection will allow taking quick, adequate and more rational therapeutic actions to provide the patients with a better quality of life.

Palabras clave : diabetes; MODY; genetics; monogenic diabetes; therapeutics.

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