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Revista Cubana de Endocrinología

versión On-line ISSN 1561-2953


MARTINEZ PEREA, Hainet Victoria  y  HERNANDEZ HERNANDEZ, Mercedes de la Caridad. Hyperthyroidism and pregnancy. Rev Cubana Endocrinol [online]. 2012, vol.23, n.3, pp.299-305. ISSN 1561-2953.

Hyperthyroidism is the most common thyroid disease in pregnancy. Diagnosing is somewhat difficult because of the physiological changes in pregnancy; it is accompanied with goiter, hypermetabolism and hyperdynamic circulation. Difficulties in gaining weight in spite of keeping appetite and tachycardia value at rest (over 90 beats per minute) are the most suggestive signs. The most common cause (80 to 85 % of cases) is Graves' disease of autoimmune etiology, which occurs more frequently in the first trimester of pregnancy and after the childbirth, and may become more severe if there are high levels of chorionic gonadotropin during the first trimester of pregnancy. Manifest hyperthyroidism affects the course of pregnancy and has adverse effects for the mother and the fetus. The determination of high levels of free thyroxine and triiodothyronine is the confirmatory diagnostic test. The use of synthesis antithyroid medication is the therapy of choice. The minimal necessary dose is recommended to control hyperthyroidism and to keep the patient in euthyroid state, and this is achieved with clinical and thyroid function follow-up every 4 to 6 weeks. The breast-feeding is allowed in mothers taking a 200 mg/day dose of propylthiouracil or 20mg/day of methimazole.

Palabras clave : hyperthyroidism and pregnancy; Graves' disease and pregnancy; transient gestational thyrotoxicosis or gestational hyperthyroidism.

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