Resumen

LEAL CURI, Lisette  y  ROBLES TORRES, Erick. Glucocorticoid resistance syndrome. Rev Cubana Endocrinol [online]. 2014, vol.25, n.3, pp.253-258. ISSN 1561-2953.

Glucocorticoids are involved in important biological processes of the body. The glucocorticoid resistance syndrome or Chrousos's syndrome is a genetic disease caused by the human glucocorticoid receptor gene mutations. It is characterized by reduced tissue sensitivity to cortisol and compensatory increase of the hypothalamus-hypophysis-adrenal axis activity, which leads to a rise of minrealocorticoids, cortisol and adrenal androgens levels. The clinical picture is variable, going from asymptomatic, mild or severe manifestations to hypertension and hyperandrogenism. For a right diagnosis, there should be no Cushing-like manifestations and biochemical hypercortisolism as well as hypothalamus-hypophysis-adrenal axis resistance to dexamethasone suppression have to be proven. The objective of the treatment is to halt the excessive secretion of the adrenocorticotrope hormone through glucocorticoids that do not present mineralocorticoid action as it happens with dexamethasone. In the near future, corrective therapies are expected to be available in order to directly fix genetic defects in the human glucocorticoid receptor gen.

Palabras clave : glucocorticoid resistance; Chrousos syndrome.

        · resumen en Español     · texto en Español     · Español ( pdf )