Abstract

MARRERO RODRIGUEZ, María Teresa; SINCONEGUI GOMEZ, Belkys  and  CRUZ CRUZ, Anaisa. Molecular markers for thyroid cancer. Rev Cubana Endocrinol [online]. 2015, vol.26, n.1, pp.93-104. ISSN 1561-2953.

The importance of the study of the thyroid nodule lies in excluding the possibility of a malignant lesion because the majority of lesions are benign but there is a malignancy risk of 5 to 10%. Most of them are well differentiated carcinomas originating in the follicular epithelium. In spite of the fact that the majority are benign lesions, distinguishing them from carcinomas is crucial to treatment and adequate follow-up. Fine-needle biopsy allows making the diagnosis in most of cases. However, this method is restricted, particularly when diagnosing follicular lesions. In an effort to improve the diagnostic accuracy of biopsy and to provide new diagnosing criteria, a number of molecular markers have been put forward, some of which has wide range of approval whereas others still awaits to be validated for further implementation. This article presented an updated review of molecular markers with higher number of evidence, more accessible and potentially usable from a methodological viewpoint for diagnosis of the thyroid nodule before surgery.

Keywords : thyroid cancer; molecular markers; fine needle biopsy; gene; mutations.

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