Revista Cubana de Higiene y Epidemiología
versão On-line ISSN 1561-3003
MAS LAGO, Pedro; FERRER GRACIAS, Helenio e GOYENECHEA HERNANDEZ, Ángel. Infección con poliovirus vacunal en niños con anticuerpos neutralizantes homólogos, inducidos por vacunaciones con VOP-T. Rev Cubana Hig Epidemiol [online]. 2003, vol.41, n.2-3, pp. 0-0. ISSN 1561-3003.
An investigation on seroconversion and circulation of the viruses excreted from the oral polio vaccine (OPV) was made for some years and its results were introduced into the improvement of the program for erradicating this disease. A retrospective analysis of the data showed new results that are still into effect in the context of the program for the world erradication of polio. 98 children under 2 were administered 2 doses of trivalent oral polyo vaccine (T-OPV) with an interval of 4 weeks. Stool samples were obtained weekly from the first dose to 4 weeks after the second dose. Serum samples were taken before vaccination and 4 weeks later. The percentage of isolation of homologous poliovirus in children with no previous antibodies is higher (116.7 %) than the one attained in children with previous antibodies (34.2 %). The percentages of total isolations from poliovirus in children with seroconversion (72.4 %) is higher than those registered in children with booster (167 %). The cases without isolations in seroconversions with previous heterologous antibodies plus the boosters without anamnestic reaction, or homologous isolations allowed to infer a selflimited silent circulation. The interference to the polioviruses by the non-polio enteroviruses, together with the increase of antibodies by the campaigns, caused that the circulations of poloivirus were selflimited shortly after concluding the mass campaign
Palavras-chave : POLIOMYELITIS [immunology]; POIOMYELITIS [PREVENTION & CONTROL]; MASS IMMUNIZATION; POLIO VIRUS VACCINE; ORAL; POLIOVIRUS VACCINES; INFANT.