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Revista Cubana de Higiene y Epidemiología

versión On-line ISSN 1561-3003

Resumen

MONTE CEPERO, Lorena  y  MARTINEZ CASANUEVA, Raiza. Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a hospital in Havana. Rev Cubana Hig Epidemiol [online]. 2021, vol.58, e412.  Epub 01-Dic-2021. ISSN 1561-3003.

Introduction:

Beta-lactamase production is the most common resistance mechanism in gram-negative microorganisms. Extended-spectrum beta-lactamases are an important group of enzymes capable of inactivating third- and fourth-generation cephalosporins and aztreonam. Their detection is important to indicate the optimum treatment as well as isolation measures aimed at preventing the spread of carrier microorganisms.

Objectives:

Determine the incidence and main characteristics of isolates of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae from non-urogenital samples.

Methods:

A cross-sectional study was conducted at Salvador Allende hospital during the year 2017. Determination was made of the frequency of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae, their origin by hospital service, the type of clinical sample and their antimicrobial sensitivity. Identification of extended-spectrum beta-lactamases was based on the Jarlier double disc method.

Results:

Of the total Escherichia coli and Klebsiella pneumoniae isolates studied, 46% and 50%, respectively, were extended-spectrum beta-lactamase producers. Most had been obtained from samples taken in wards of the Institute of Angiology; the most effective antimicrobial was meropenem; sensitivity to the remaining antimicrobials was below 80%; no isolates were sensitive to third-generation cephalosporins.

Conclusions:

A high incidence was found of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates at Salvador Allende Hospital in Havana, more noticeably in Institute of Angiology wards and skin samples.

Palabras clave : E. coli; K. pneumonia; extended-spectrum beta-lactamases; beta-lactam antibiotics.

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