Abstract

RIEUMONT, Emilia Rosa et al. Immune response after vaccination for hepatitis B and tuberculosis in children under 10. Rev Ciencias Médicas [online]. 2009, vol.13, n.1, pp.52-61. ISSN 1561-3194.

Controlling infectious deseases constitutes one of the top priorities of the Ministry of Public Health in Cuba, and in those diseases that there is an efficient vaccine for prevention and complete elimination, knowing its immunogenicity is oriented by means of interventionist and lifetime research. In this study both, antihepatitis B and BCG were included, constituting also part of the National Program of Immunization. In this study, the cell response was evaluated by means of the inmunoenzimatic method (ELISA) for antihepatitis B, and the observation of scar or trace for BCG in 498 children born in 1994 and living in Consolación del Sur, Pinar del Río province, that had previously received a scheme for both vaccines during their chilhood. Associations in immune responses for both vaccines were determined after 10 years. Newborn with normal weight had a protection effect for BCG immune response, however, for antihepatitis B and low weight newborn, a high statistical significance was observed in those that did not get Seroprotection levels. Despite of this, the quality of the vaccines was proved, evidenced by the absence of infection markers for both diseases.

Keywords : Infectious deseases/ epidemiology; bcg and antihepatitis b/ vaccines; immune response/ immunology; national program of immunization/ prevention and control.

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