Abstract

RIEUMONT, Emilia Rosa; MARTINEZ GUTIERREZ, José Fco; CRUZ GONZALEZ, Tania  and  LUGO ROSA, María Gloria. Immnune response to the Heberbiovac-HB and risk factors, Consolación del Sur 2004. Rev Ciencias Médicas [online]. 2009, vol.13, n.2, pp.90-100. ISSN 1561-3194.

One of the mainstays to control and eliminate hepatitis-B is the use of the vaccines (Herberbiovac-HB) applied in Cuba since 1992. The immunogenicity, an indicator obtained through the quantification of the Antibodies Titers (Anti-HBs) against the surface antigens (HbsAg) post-vaccination, allowing knowing the effectiveness and quality of the vaccine. The immunoenzymatic method was used in this study kind of sandwich (ELISA), carried out by the Department for the study of Hepatitis B of the Immunology Laboratory in the National Center of Medical Genetics, Havana City. The individuals which results were between =10 UI/L and < 100 UI/L, Hyperresponsers = 100 UI/L are considered protected and sero-unprotected when the titers were < 10 UI/L; in 498 children of 10 years old that were vaccinated in the early childhood having the schedule (0-16 months) of negative mothers for HBsAg, belonging to Consolacion del Sur in Pinar del Rio province. Results showed that male sex, Hypersensibilities Type I and the boys and girls maintaining treatments with immunosupresor drugs were the risk factors that provided the association with the serum-unprotection; as for in the individuals having Titers of Ac < 10 UI/L; a buster of the vaccine was applied and after 15 days the 100% of them achieved the values of serum-protection, calculating the geometric media to 35.1 UI/L before the reinforcement of the vaccine and after it 109.5 UI/L.

Keywords : Immunization Program; Hepatitis B Vaccines; Immunology; Surface Antigens/hepatitis B; Anti-HBs; analysis.

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