Abstract

SANDRINO SANCHEZ, Maribel et al. Interstitial pulmonary disease caused by amiodarone: a case report. Rev Ciencias Médicas [online]. 2012, vol.16, n.4, pp.148-157. ISSN 1561-3194.

A 62 year-old, Caucasian, female patient having health personal records of paroxysmal supraventricular tachycardia maintaining a daily treatment with amiodarone (400mg) during 4 years presented a respiratory disorder characterized by dyspnea at middle and  great efforts, not intense cough with whitish and scarce expectoration. The patient attended to the emergency room at “Leon Cuervo Rubio” General Hospital in Pinar del Rio. Physical examination showed the presence of crepitus-indux in the inferior third of left pulmonary field and the base of the right lung; X-ray of thorax proved a diffuse opacity having cottony aspect in the inferior half of both pulmonary fields presenting inflammatory features. The patient was admitted to complete a clinical study and pharmacological treatment. Considering the clinical evolution of the patient and radiological findings, antibiotic therapy was indicated without radiological improvement due to the extension of lesions, then deepening in the clinical study. Amiodarone was discontinued, and the treatment with steroids started, showing improvement of the symptoms, where the disappearance of crepitus-indux was clear; from radiological point of view a remarkable progress was observed. The patient was discharged from the hospital with steroid treatment and the follow-up was recommended, and at month there were no symptoms with a marked radiological improvement; a progressive diminution of steroid and monitoring of the patient in the health area was decided. The experiences derived from this case report are presented. In Cuban medical literature no similar cases were found.

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