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Revista de Ciencias Médicas de Pinar del Río

versión On-line ISSN 1561-3194

Resumen

GONZALEZ ARMAS, Eilín  y  CABEZAS ALFONSO, Hildefonso Caridad. Acid folic effects over morphometric variables in newborn Wistar rats. Rev Ciencias Médicas [online]. 2015, vol.19, n.4, pp.652-659. ISSN 1561-3194.

Introduction: folic acid consumption represents a health problem worldwide, while several congenital defects are considerable as preventable with enough level of folic acid in mothers. Objective: to show the effects of acid folic over some morphometrical variables in newborn Wistar rats. Material and method: an experimental analytic study was carried out in 116 newborn Wistar rats. The variables used are: tail length, biparietal diameter, and body mass. Five groups of two rat each were made up: one target group and four groups treated with folic acid, taking into account dosis and gestation time; the measuring were made on the first and third day after the rats’ birth. The variable analysis were carried out by the calculation of the mean and stadard deviations, and for comparisson of the average numbers a level of significance α ≤0,05 were used. Results: the measuring of the tail length showed statistical significance (P<0.05) when the target group and the treated groups were compared, the variables biparietal diameter and body mass did not present any statistical significance despite the fact that the measures of the variable body mass in the treated groups were higher than in the target group. Conclusions: the need for acid folic supply before and during gestation in Wistar rats was proved, due to its influence as cofactor during the fetal life, stimulating the secretion of any of the growing factors during the postnatal life.

Palabras clave : Folic acid; Biparietal diameter; Tail length; Body mass.

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