Introduction:

hypernephroma represents 2 % to 3 % of all adult malignant neoplasms. Its metastatic patterns have not been precisely defined. Duodenal metastasis is considered rare when it occurs.

Case Report:

a 48-year-old-male patient, having a history of right nephrectomy due to hypernephroma, at 7 months after the surgery a spread to the lung and renal fossa was found. One year after nephrectomy he was evaluated for chronic anemia, positive fecal occult blood and gastrointestinal symptoms. An opaque colon enema was performed which revealed infiltration of the wall and during gastroscopy a sample of tumor lesion in the duodenum was taken. The pathological analysis of the duodenal biopsy showed an anaplastic large cell tumor lesion with vacuolated cytoplasm, PAS positive and PAS Diastase negative, compatible with metastasis of renal cell carcinoma.

Conclusions:

the late appearance of metastases and spontaneous regression of hypernephroma require a comprehensive and prolonged follow-up by the medical staff in charge, in those where the suspicion of dissemination should always prevail during the clinical approach, even when the clinical picture does not suggest the most common sites.

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