Background:

Faced with the need to constantly improvement of the analytical methods and interpretation of results in clinical investigations to identify prognostic factors, a methodology that allowed the efficient use of statistical implicative analysis in these investigations was created.

Objective:

To describe the methods and procedures used in each of the research phases to obtain the proposed methodology.

Methodology:

A documentary review of the proper validation methods was carried out, taking advantage of the bibliographic databases from Internet, which was compared with the authors´ experience to conform the design and validation of the proposal.

Development:

The research was carried out in 5 stages: the theoretical-practical foundation of the usefulness of this analysis, the preparation of the proposal, the validation by three routes (criteria, content and a meta-analysis) and the final design of the methodology.

Conclusions:

In spite of the variety of validation forms used, the application of the methodology continues to detect possible deviations in the analysis and interpretation to be solved in the future.

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