Resumen

TRIANA MANTILLA, María Eugenia. Lecithin: cholesterol acyltransferase and the carotid disease. Rev Cubana Angiol Cir Vasc. [online]. 2014, vol.15, n.2, pp. 171-182. ISSN 1682-0037.

Introduction: lecithin:cholesterol acyltransferase is the enzyme in charge of esterifying the free extracellular cholesterol and of helping in the conversion of high density lipoprotein sub-fractions, but its role in the carotid disease is still unknown. Objective: to identify the role of lecithin: cholesterol acyltransferase in the carotid disease, and whether it may be considered as a biomarker of the disease. Methods: the databases MedLine, PubMed, SciELO, Web of Science, and Cuban biomedical journals of last five years (2009-2013) were reviewed. The subject headings were lecithin: cholesterol acyltransferase, dyslipidemia, carotid atherosclerosis, carotid disease. Information synthesis: there is evidence supporting the reverse relation of high density lipoprotein-transported cholesterol and the carotid disease and of the participation of lecithin: cholesterol acyltransferase in the metabolism of these lipoproteins. However, the evidence point out that lecithin: cholesterol acyltransferase is not necessary for vascular protection and the "anti-atherogenic" effect of the enzyme depends on the quality of the said lipoproteins and the genetic component. Conclusions: there are not enough results that allow identifying the causative relationship between lecithin: cholesterol acyltransferase and the carotid disease, since the results are not conclusive, and this enzyme cannot be considered so far a predictive biomarker of the disease.

Palabras clave : lecithin; cholesterol acyltransferase; dyslipidemia; carotid atherosclerosis; carotid disease; extracranial cerebrovascular disease.

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