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Revista Cubana de Angiología y Cirugía Vascular

versión On-line ISSN 1682-0037

Resumen

FEITO CASTEX, Teresita Regina et al. Characterization of patients with peripheral arterial disease treated with autologous mononuclear cells. Rev Cubana Angiol Cir Vasc [online]. 2020, vol.21, n.2, e91.  Epub 01-Ago-2020. ISSN 1682-0037.

Introduction:

Low limbs´ arterial occlusive disease is associated with a high rate of amputations and risk of death. Regarding that, regenerative medicine has proven satisfactory results.

Objective:

To characterize patients with peripheral arterial disease in the low limbs which have been treated with autologous mononuclear cells.

Methods:

It was carried out a prospective longitudinal research in “Arnaldo Milián Castro” Hospital in the period from January, 2015 to December, 2017. From a population of 61 patients, it was intentionally selected by criteria a sample of 52 individuals.

Results:

The average age was 66,9 ± 8,2 and 69,2% were men. The main vascular risk factors were smoking habit, hypercholesterolemia and arterial hypertension. The level of occlusion showed predominance of femoro-popliteal and the bad output tractus was the main cause of non-revascularization. Cell viability was high and it was achieved a significant change in Fontaine stages. The beginning of a clinical improvement happened between the first and the second month in most of the cases. In some patients were open post-surgical possibilities and it was obtained great tisular reperfusion.

Conclusions:

The implant of autologous mononuclear cells in patients with peripheral arterial disease of low limbs represents an useful and effective new strategy of therapeutic angiogenesis which opens new treatment perspectives.

Palabras clave : Peripheral arterial disease; autologous mononuclear cells; amputation.

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