Resumo

MISIARA ALVAREZ, Alfredo Ediel et al. First report of toxic epidermal necrolysis due to oral antibiotic in Gambia. Rev.Med.Electrón. [online]. 2017, vol.39, n.6, pp.1319-1327. ISSN 1684-1824.

The most frequent drug adverse reactions are the skin ones, occurring in 2 % of the treatments; most of the times the diagnosis is reached by exclusion. The most feared one is the toxic epidermal necrolysis, presenting yearly up to 4 cases per million of inhabitants with a mortality occasionally reaching 70 %.  The objective was presenting the case of a patient with toxic epidermal necrolysis because of the rarity of this disease, its high mortality and characteristic clinical evolution. The patient was a Gambian aged 29 years, with health antecedents, who after beginning an outpatient treatment with oral antibiotic for a facial pyodermitis, presented bullous lesions extended throughout all the body. The patient received support treatment, oral steroidal treatment and oral, parenteral and topic treatment with a wide spectrum antibiotic; after a 30-days unfavorable evolution, he died.  It was thought-provoking the absence of mucous lesions in spite of the total extension of the skin lesions. It was difficult the management of this patient in a peripheral hospital without the adequate therapeutic arsenal nor the suitable unit for his care.

Palavras-chave : toxic epidermal necrolysis; drug toxic reactions.

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