Resumo

GONZALEZ SOSA, Gabriel  e  PINOL JIMENEZ, Felipe. Etiopathogeny of the non-variceal high digestive hemorrhage, inflammatory answer and Helicobacter pylori. Rev.Med.Electrón. [online]. 2018, vol.40, n.1, pp.159-171. ISSN 1684-1824.

ABSTRACT The infection by Helicobacter pylori occurs worldwide, although it is more frequent in developing countries and in communities with poor socioeconomic conditions, where there is overcrowding or migration from regions of high prevalence. The infection occurs mainly during the childhood and increases with age. An exhaustive review was carried out where the mechanisms unchaining the inflammatory answer after the bacteria colonizes the stomach are explained in an explicit way. It has two stages: the first one is characterized by the microorganism arrival and penetration to the gastric mucus, where it settles and multiplies, and the second stage characterized by an amplification of the inflammatory answer. The knowledge of these etiopathogenic mechanisms does not only help the eradication of the bacteria but also contributes to the regulation of the neuroimmune system before, during and after tissue damage, for reaching an adequate tissue regeneration, improving the functional capacity  of the bleeding organ, and preventing  the disease torpid evolution.

Palavras-chave : helicobacter pylori; etiopathogenic mechanisms; neuroimmune system.

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