Resumo

MONTESINO CASTILLO, Susana Margarita; YERA GALVEZ, Cristóbal  e  HERNANDEZ CACERES, José Luis. Resonant Recognition Model Study for Interactions between SARS CoV 2 and Human Proteins. RCIM [online]. 2021, vol.13, n.1  Epub 01-Abr-2021. ISSN 1684-1859.

This study was devoted to the Resonant Recognition Model (RRM) analysis of SARS-CoV-2 proteins and their possible interaction with other human proteins, specifically, SARS CoV replicases and methyl transferases, were tested, via RRM analysis, for possible interactions with host CD4 T receptor proteins and prohibitins which participate in human organism response to viral infections. The following protein sequences were studied: twenty human SARS coronavirus methyltransferase proteins, eight replicase proteins, twenty-one prohibitin proteins, and eleven CD4 -T-cell surface antigens T4 proteins. Results revealed RRM peaks at f1=0.07349 and f2=0.2839. The peak at f1 was also common for interaction between SARS-CoV-2 methyl transferases and human prohibitins, where opposite phase suggest binding between these proteins during viral infection. This interaction was not supported for viral methyltransferase and human CD4 receptors (72.4 o phase shift). Viral replicases exhibited opposite phase interaction with both prohibitins and CD4 receptors. Overall, RRM revealed common RRM frequencies for both replicases and methyl transferases, and added plausibility to interactions between SARSCoV2 methyl transferase and human prohibitin, as well as between SARS Cov2 replicase and human prohibitin and CD4 T-cell receptors.

Palavras-chave : SARS-CoV-2; replicase; methyl transferase; Resonant Recognition Model; CD4 T receptor; prohibitin.

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