Resumen

BARLETTA FARIAS, Roberto et al. Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic. Medisur [online]. 2018, vol.16, n.2, pp.322-334. ISSN 1727-897X.

In the last years Acinetobacter baumannii has become one of the germs of higher clinical relevance, which really turns it into a paradigm in the nosocomial multi-drug resistant infections. The present work had the objective of describing the resistance mechanisms of Acinetobacter baumannii to multiple drugs, so as to explain current therapeutic strategies in multidrug-resistant strains; for that 37 bibliographic resources were consulted. The mechanisms involved in the micro-organism resistance include inhibition to the antibiotic by β-lactamases, decreasing of antibiotic permeability due to porin loses, presence of efflux pumps and drug action site disturbances. It is recommended that the treatment of choice in multi-drug resistant strains is colistin and tigecycline, though other drugs may be used so as their combination.

Palabras clave : Acinetobacter baumannii; drug resistance, microbial; drug therapy.

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