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MediSur

On-line version ISSN 1727-897X

Abstract

PENA BATISTA, Andrés Pavel et al. Functional ventilatory alterations in adult patients with sickle cell disease. Medisur [online]. 2020, vol.18, n.1, pp.50-57.  Epub Feb 02, 2020. ISSN 1727-897X.

Foundation:

in patients with sickle cell disease, lung function abnormalities are frequent and can be detected by spirometry.

Objective:

to describe the disturbances of the respiratory functions in patients with sickle cell disease followed in a provincial consultation of hemoglobinopathies.

Methods:

observational, descriptive, cross-sectional study. Seventy six patients, selected by accidental non-probabilistic sampling, of 88 adults followed at the Dr. Gustavo Aldereguía Lima Hospital were included. The variables studied were: age, sex, type of hemoglobinopathy, respiratory symptoms, history of acute thoracic syndrome, (clinical forms and number of events), comorbidities and ventilatory pattern. Functional ventilatory tests were performed with Hellige digital Microspiro.

Results:

the age group between 20-29 years was the most frequent (34.2%). There was a discrete female predominance (56.1%) and the SS genotype (67.1%). The most frequent of the respiratory symptoms was dyspnea and among the comorbidities heart failure in 9.2% of the patients. In 42.1% there was a history of acute chest syndrome, pneumonia in most cases. Nine patients (11.8%) presented obstructive disorders and 43 patients (56.6%) a restrictive pattern. In the SS genotype the risk of having spirometry alterations was three times higher than the rest [OR = 3.2 IC (1.7-5.9)]

Conclusion:

the finding of altered respiratory functional test with a predominance of the restrictive pattern was common. These modifications were observed more frequently in patients with the SS genotype.

Keywords : anemia; sickle cell; respiration; spirometry.

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