Abstract

PEREZ-OLIVA DIAZ, Jorge et al. Elevated C reactive protein and hypoalbuminemia. Complex syndrome: malnourishment: chronic microinflamation, atherosclerosis: prognosis significance in patients under hemodyalisis. Rev haban cienc méd [online]. 2009, vol.8, n.1, pp. 0-0. ISSN 1729-519X.

Mortality is very hight in patients with end-stage renal disease. The leading cause of death is cardiovascular disease and sepsis. The presence of micro-inflammation, is evidenced by increased levels the acute-phase proteins (C-reactive protein), has been found to be associated with vascular disease in dialysis patients Hypoalbuminemia, ascribed to malnutrition, has been one of the most powerful risk factors that predict all-cause and cardiovascular morbidity and mortality in dialysis patients. The purpose of this study was to describe the prognostic significance in haemodialysis patients with this state. The prospectively study in 107 ESRD patients receiving chronic haemodialysis treatment cohort was then followed-up prospectively for 24 month are formulate. The prevalence of hight PCR are 42,99 %,(22,42-44,25), of hypoalbuminemia 33,33%,(22,42-44,25), were also independently predictive of cardiovascular hospitalization ,hs-CRP (OR: 2,50, IC 95% 2,02-3,14), albumin (OR: 1,50, IC 95% 1,21-2,79), and non cardiovascular hospitalization: tunneled catheter as opposed to a fistula (OR: 11,23, IC 95% 7,42-17,03), hs-CRP (OR: 10,43, IC 95%6,72-16,17), and were also independently predictive of cardiovascular mortality CRP (OR: 2,79, IC 95% 2,25-3,61), non albumin (OR: 0,80, IC 95% 0,70-0,92), and non cardiovascular hospitalization: tunneled catheter as opposed to a fistula (OR: 9,35, IC 95% 6,43- 11,21). Increased in a single circulating inflammatory proteins(hs-CPR) and decreced the albumin levelspredict determine a worse prognosis in hemodialysis patients.

Keywords : C-reactive protein; hypoalbuminemia; malnutrition; hospitalization; cardiovascular mortality and general mortality; chronic kidney disease-V; end stage kidney disease.