Revista Habanera de Ciencias Médicas
versão ISSN 1729-519X
HERNANDEZ FERNANDEZ, Rolando A. Kinases and phosphatases: the life´s yin yan. Rev haban cienc méd [online]. 2012, vol.11, n.1, pp. 15-24. ISSN 1729-519X.
Introduction: opposite forces in the inside of a process are the main sources for development. Objective: the principal mechanism to control most biological processes is the postranslational modifications of proteins. Among these the phosphorylation/ ephosphorylation cycle is the most extended in nature. Phosphorylation or dephosphorylation of proteins causes a conformational change that modifies their activities, properties, celular localization and interactions with other molecules. Results: kinases and phosphatese are the main enzymes implied in this cycle which coordinated and opposite actions give the mechanistic support for several cellular functions. Conclusions: by mean of an study about the involvement of kinases and phosphatases in cell division, this paper tray to show that these enzymes represent the molecular expression of the yin and yan, the opposite element on ancient Chinese philosophy.
Palavras-chave : mitotic kinases; mitotic phosphatases; cell division; mitosis.