SciELO - Scientific Electronic Library Online

 
vol.12 issue1Dr. Eliecer Encinosa García-Espinosa. A life devoted to the cuban revolutionary medical serviceAutoimmune response in patients with genetic diseases and immune system deregulation author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO

Share


Revista Habanera de Ciencias Médicas

On-line version ISSN 1729-519X

Abstract

HERNANDEZ FERNANDEZ, Rolando A. Ubiquitin-proteasome pathway to built or to destroy? that is the question. Rev haban cienc méd [online]. 2013, vol.12, n.1, pp.22-34. ISSN 1729-519X.

Introduction: the generation of new cells is an extremely complex process. To become this process unidirectional and irreversible cells destroy proteins which actions are oppose to the transition from one phase to the next one. Objective: to show that protein destruction is essential for cell reproduction. Material and Methods: more than 500 papers published during the last five years in national and international journals were analyzed. These articles are available in HINARI, PubMed, and Perii databases and were localized through infomed. Development: first, the ubiquitin-proteasome pathway is presented. Next, the contribution of the complexes SCF an anaphase promoting complex to the progression of the cell cycle is analysed. These complexes act consecutively and coordinately and their actions determine de progression of the cell´s life. Conclusions: the selective destroy of specific proteins by mean of ubiquitin-proteasome pathway, allow new cells formation, and ensure the continuity of life

Keywords : ubiquitin; ubiquitin-ligase; SCF complex; APC complex; cell cycle.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )