SciELO - Scientific Electronic Library Online

 
vol.12 número1Dr. Eliecer Encinosa García-Espinosa. Una vida dedicada al servicio médico revolucionario cubanoRespuesta autoinmune en pacientes con enfermedades genéticas y desregulación del sistema inmune índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Habanera de Ciencias Médicas

versión On-line ISSN 1729-519X

Resumen

HERNANDEZ FERNANDEZ, Rolando A. Ubiquitin-proteasome pathway to built or to destroy? that is the question. Rev haban cienc méd [online]. 2013, vol.12, n.1, pp.22-34. ISSN 1729-519X.

Introduction: the generation of new cells is an extremely complex process. To become this process unidirectional and irreversible cells destroy proteins which actions are oppose to the transition from one phase to the next one. Objective: to show that protein destruction is essential for cell reproduction. Material and Methods: more than 500 papers published during the last five years in national and international journals were analyzed. These articles are available in HINARI, PubMed, and Perii databases and were localized through infomed. Development: first, the ubiquitin-proteasome pathway is presented. Next, the contribution of the complexes SCF an anaphase promoting complex to the progression of the cell cycle is analysed. These complexes act consecutively and coordinately and their actions determine de progression of the cell´s life. Conclusions: the selective destroy of specific proteins by mean of ubiquitin-proteasome pathway, allow new cells formation, and ensure the continuity of life

Palabras clave : ubiquitin; ubiquitin-ligase; SCF complex; APC complex; cell cycle.

        · resumen en Español     · texto en Español     · Español ( pdf )