Resumo

GARCIA TRIANA, Bárbara E; SALDANA BERNABEU, Alberto  e  SALDANA GARCIA, Leticia. Oxidative stress and antioxidants in cancer prevention. Rev haban cienc méd [online]. 2013, vol.12, n.2, pp.187-196. ISSN 1729-519X.

Introduction: oxidative stress is involved in carcinogenesis. Consequently, the reinforcement of cellular defensive antioxidant mechanisms has been considered as strategy for cancer prevention. Objective: to evaluate the role of oxidative stress in the carcinogenesis process as well as the utility and modalities of the use of antioxidants in cancer prevention. Methods: a review was performed through the consultation of Google, LILACS, PubMed and Hinari. Review articles published in the last five years, systematic reviews and meta-analysis about the evaluation of antioxidants for cancer prevention were selected. Results: the carcinogenic mechanisms of oxygen reactive species, and the benefits and threats of antioxidant supplementation are discussed. Finally, the possible impact on oxidative stress control, of implementation of the WHO Global Strategy on Diet Physical Activity and Health is analyzed, empathizing in the anticarcinogenic mechanisms of different phytochemicals. Conclusions: the promotion of healthy habits which avoid the generation of oxygen reactive species, together with the intake of antioxidants as dietary components could lead to the appropriate balance oxidants/antioxidants and consequently to cancer prevention.

Palavras-chave : cancer; carcinogenesis; oxidative stress; oxygen reactive species; antioxidants.

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