SciELO - Scientific Electronic Library Online

 
vol.16 número3Profesores cubanos enseñando Medicina, en un país árabe, en inglésSusceptibilidad antimicrobiana en muestras clínicas de pacientes con infecciones asociadas a la atención de salud índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Habanera de Ciencias Médicas

versión On-line ISSN 1729-519X

Resumen

PAJARO-CASTRO, Nerlis; BUSTAMANTE-DIAZ, Jesús  y  IBANEZ-BERSINGER, Cristhian. Identification in silico of potentially inhibitive molecules of CDK5, protein related with the Alzheimer´s disease. Rev haban cienc méd [online]. 2017, vol.16, n.3, pp.325-336. ISSN 1729-519X.

ABSTRACT Introduction: The illness of Alzheimer exhibits a neurodegenerative and irreversible commitment. Today, numerous investigations promote the inhibition of some kinases to the treatment, of special mention the CDK5. Objective: Identification of new molecules witch are able to interact with the cicline dependent kinase protein 5, CDK5, inhibiting their function. Material and Methods: it was carried out a study in silico, for that 911 pubchem molecules were extracted, and by means of AutoDock Vina molecular joining were made with the protein CDK5 extracted from the Protein Data Bank and with a well-known inhibitor for the protein. It was also carried out an inverse joining for the identification of other possible molecular targets with the best selected ligands. Results: With the obtained results five molecules were identified with values of likeness among -11,6 until -17,7 Kcal/mol that joins in the active site of the protein, in the same form that makes it the well-known inhibitor of the CDK5, and interact with the residuals cysteine 83 and glutamine 81. Conclusions: The identified molecules can interact with the CDK5 at level of their active place, for what you/they could act as inhibitors of this quinasa. This opens a future therapeutic window in the treatment of the illness of Alzheimer.

Palabras clave : Molecular joining; active site; Alzheimer; CDK5; in silico.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons