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Revista Habanera de Ciencias Médicas

versión On-line ISSN 1729-519X

Resumen

NUNEZ CAIRO, Carlos Rafael; ZUMETA DUBE, Melvis Taylín; PAZO BOU, Noemí  y  IGLESIAS DOCINA, Evelyn. Effects of Epidermal growth factor on histological features of the kidney in rats with Chronic kidney failure. Rev haban cienc méd [online]. 2020, vol.19, n.4, e3048.  Epub 10-Sep-2020. ISSN 1729-519X.

Introduction:

Chronic Kidney Failure is a public health problem; therefore, the need for actions aimed at its prevention, diagnosis and effective therapeutic interventions is a most. Recent studies use the Epidermal Growth Factor to evaluate its reno-protective effect on functional variables; however, there are no studies related to the effects of this product on histological features of kidney in chronic failure.

Objective:

To determine the possible protective and / or repair effects of recombinant human epidermal growth factor on the histological features of kidneys in chronic renal failure.

Material and methods:

We worked with three series, each consisting of a control group and an experimental group of five animals. The experimental groups underwent 5/6 surgical ablation of the renal mass. Series A consisted of control animals, series B included those animals treated with Epidermal Growth Factor 24 hours before the procedure and series C was made up of those animals treated with the bioproduct 24 hours after the procedure. Fifty-six days after surgical act, euthanasia was practiced on the animals and the kidneys were histologically studied.

Results:

Histological alterations were observed in the renal corpuscles and tubules in the animals included in series A; in series B it was observed that most of the renal parenchyma presented normal characteristics and those in series C showed increased kidney damage.

Conclusions:

Recombinant human epidermal growth factor has a reno-protective effect; however, it does not offer a repair effect of acute kidney.

Palabras clave : Animal model; Chronic Renal Failure; histology of the kidney; Epidermal Growth Factor.

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