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Revista Habanera de Ciencias Médicas

versión On-line ISSN 1729-519X


NUNEZ CAIRO, Carlos Rafael; ZUMETA DUBE, Melvis Taylín; PAZO BOU, Noemí  y  IGLESIAS DOCINA, Evelyn. Effects of Epidermal growth factor on histological features of the kidney in rats with Chronic kidney failure. Rev haban cienc méd [online]. 2020, vol.19, n.4, e3048.  Epub 10-Sep-2020. ISSN 1729-519X.


Chronic Kidney Failure is a public health problem; therefore, the need for actions aimed at its prevention, diagnosis and effective therapeutic interventions is a most. Recent studies use the Epidermal Growth Factor to evaluate its reno-protective effect on functional variables; however, there are no studies related to the effects of this product on histological features of kidney in chronic failure.


To determine the possible protective and / or repair effects of recombinant human epidermal growth factor on the histological features of kidneys in chronic renal failure.

Material and methods:

We worked with three series, each consisting of a control group and an experimental group of five animals. The experimental groups underwent 5/6 surgical ablation of the renal mass. Series A consisted of control animals, series B included those animals treated with Epidermal Growth Factor 24 hours before the procedure and series C was made up of those animals treated with the bioproduct 24 hours after the procedure. Fifty-six days after surgical act, euthanasia was practiced on the animals and the kidneys were histologically studied.


Histological alterations were observed in the renal corpuscles and tubules in the animals included in series A; in series B it was observed that most of the renal parenchyma presented normal characteristics and those in series C showed increased kidney damage.


Recombinant human epidermal growth factor has a reno-protective effect; however, it does not offer a repair effect of acute kidney.

Palabras clave : Animal model; Chronic Renal Failure; histology of the kidney; Epidermal Growth Factor.

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