SciELO - Scientific Electronic Library Online

vol.19 número4Efectos del Factor de crecimiento epidérmico sobre las características histológicas del riñón en ratas con Insuficiencia renal crónicaRepercusiones de la pandemia de COVID 19 en la atención odontológica, una perspectiva de los odontólogos clínicos índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO


Revista Habanera de Ciencias Médicas

versión On-line ISSN 1729-519X


CUELLO ALMARALES, Dany A.; ALMAGUER MEDEROS, Luis E.  y  ALMAGUER GOTAY, Dennis. Potential therapeutic use of RNA interference against COVID-19. Rev haban cienc méd [online]. 2020, vol.19, n.4, e3400.  Epub 10-Sep-2020. ISSN 1729-519X.


SARS-CoV-2 is the causal agent of COVID-19, a respiratory disease that has caused thousands of deaths globally for which there is no effective curative therapy.


To demonstrate the potential relevance of RNA interference (RNAi) technology as a therapeutic alternative in the treatment of COVID-19.

Materials and methods:

Specialized biomedical databases were searched looking for studies published until April 2020. The search was carried out using descriptors and Boolean operators. Advanced search strategy was used for the selection of articles, taking into account the methodological quality and validity of the studies.


Evidence of experimental application of RNAi technology against SARS-CoV was identified. Several small interfering RNAs and small loop-structured RNAs oriented to the silencing of essential SARS-CoV genes including those encoding the S, RdRp, M, E, N, 3a/3b and 7a/7b proteins have been designed and evaluated. The effectiveness of RNAi for silencing its target genes was proven. Although most of these research studies have been conducted in in vitro systems, the therapeutic effectiveness of the intranasal administration of small RNA interference has also been proven in an in vivo SARS-CoV model.


RNAi technology has demonstrated to be a potential therapeutic strategy against SARS-CoV in cellular and animal models. Given the similarities at the genomic level and in terms of the pathogenic process between SARS-CoV and SARS-CoV-2, this technology has a potential applicability for the treatment of COVID-19.

Palabras clave : COVID-19; SARS-CoV; SARS-CoV-2; RNA interference; antiviral therapy.

        · resumen en Español     · texto en Español     · Español ( pdf )