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Revista Habanera de Ciencias Médicas

versión On-line ISSN 1729-519X

Resumen

SOSA FRIAS, Alexander; VERGARA SANTOS, Aimara de la C.  y  MOJENA MOJENA, Oreste. Predictive factors of unsatisfactory evolution among 20-65 year-old patients infected with COVID-19. Rev haban cienc méd [online]. 2021, vol.20, n.3, e3937.  Epub 16-Jun-2021. ISSN 1729-519X.

Introduction:

Several authors validated the use of clinical, humoral, and radiological indicators as predictors of unsatisfactory evolution in patients with COVID-19.

Objective:

To evaluate the clinical-humoral variables and the findings in the first chest x-ray as predictors of unsatisfactory evolution in patients with COVID-19.

Material and Methods:

An observational and retrospective case-control study was carried out in 484 patients infected with COVID-19 admitted to the Cuban Hospital of Qatar between March and July 2020. The sample was composed of 60 patients. Cases: patients with respiratory failure who required invasive ventilation or death. Controls: patients with COVID-19 without complications. Input variables: age, sex, BMI, presence of comorbidities, leukocyte value, and severity index of the first chest x-ray. Response variable: clinical evolution. The bivariate analysis was performed using the Chi-square test. In the multivariate analysis, using binary logistic regression, p values ​​lower than 0.05 were considered significant. The results were expressed in the Odds Ratio.

Results:

The progression of age, belonging to the group of 61-65 years, female sex, suffering from diabetes or arterial hypertension, having two comorbidities, abnormal leukogram, and the severity index of the first chest X-ray between 2-6 / 6 were related to unsatisfactory evolution. The leukogram (ODDS RATIO 68.634 p = 0.000) and the severity index of the first chest x-ray (ODDS RATIO 12.201 p = 0.008) have an independent influence on patients with COVID-19.

Conclusion:

The predictive value of the leukogram and the severity index in the first chest x-ray over unsatisfactory evolution were demonstrated in these patients.

Palabras clave : Tomography; pneumonia; COVID-19; respiratory insufficiency; SARS-CoV-2.

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