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Revista Habanera de Ciencias Médicas

versão On-line ISSN 1729-519X

Resumo

RODRIGUEZ REYES, Oscar et al. Effect of 4-Chlorophenol on the vascular smooth muscle of the abdominal aorta of Wistar rats. Rev haban cienc méd [online]. 2021, vol.20, n.4, e3901.  Epub 10-Ago-2021. ISSN 1729-519X.

Introduction:

In Dentistry, p-chlorophenol (4-chlorophenol) is one of the most widely used derivatives of chlorophenols. It is used as an antibacterial agent in root canal disinfection during pulp-radicular treatment. There are few scientific reports on its effects on vascular smooth musculature and the regulation of local blood flow.

Objective:

To determine the effect of 4-chlorophenol on vascular smooth muscle of abdominal aorta from Wistar rats.

Material and Methods:

A preclinical experimental research was carried out using 30 abdominal aortic rings (upper portion) obtained from adult Wistar rats. The preparations of about 5 mm were placed in an organ bath, recording the tension developed by the vascular smooth muscle after the addition of 4-chlorophenol at different concentrations and during different time intervals.

Results:

The results demonstrate that 4-Chlorophenol induced vasorelaxation after the preactivation of the vascular smooth muscle of the abdominal aortic rings, which increased during the entire study time and with increased drug concentration. There were significant differences among average tension values registered at different intervals of time in relation to the initial base tension.

Conclusions:

It is concluded that in vitro, p-chlorophenol induced relaxation of abdominal aorta vascular smooth muscle in Wistar rats.

Palavras-chave : vascular smooth muscle; vascular tone; vasodilation; aorta; contraction; 4-Chlorophenol.

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