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Revista Cubana de Reumatología

versión On-line ISSN 1817-5996


HERNANDEZ MUNIZ, Yanileydys et al. Risk factors for the development of atherosclerosis in patients with rheumatoid arthritis. Rev Cuba Reumatol [online]. 2019, vol.21, n.3, e106.  Epub 01-Dic-2019. ISSN 1817-5996.


rheumatoid arthritis is a systemic disease, of unknown etiology, characterized by chronic inflammation; It presents with joint, extra-articular manifestations and variable clinical behavior.


to characterize the risk factors for the appearance of atherosclerosis in patients with rheumatoid arthritis and to identify their relationship with the time of diagnosis, inflammatory activity and treatment.


a cross-sectional, descriptive study was conducted in patients with rheumatoid arthritis treated at the Rheumatology Center of the Surgical Clinical Teaching Hospital 10 de Octubre in the period between February 2016 and June 2017.


the highest frequency was for the female sex, the age range 45-54 years. Atheromatous plaque was observed in 37.2 % and intimal complex thickening in 15.4 %. The risk factors that showed association with the presence of plaque were: hypertriglyceridemia (p= 0.000), hypercholesterolemia (p= 0.000), Diabetes Mellitus (p= 0.027) and high levels of C-reactive protein (p= 0.003)


the traditional risk factors that presented statistical significance were hypercholesterolemia, hypertriglyceridemia and Diabetes Mellitus. The presence of more than one traditional risk factor increased the frequency of alterations in Doppler echo; There was an association between the elevation of C-Reactive Protein levels and the presence of Doppler echo alterations. It was found in those patients with carotid echo Doppler alterations, relationship with the time of evolution, activity of the disease and cumulative dose of steroids.

Palabras clave : atheromatous plaque; thickening intimate middle complex; atherosclerosis; risk factor.

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